zimeta For Sale

Zimeta is indicated for the control of pyrexia in horses. In clinical studies, Zimeta™ demonstrated rapid and effective control of fever in horses.1,2*  In a field study, clinical signs associated with adverse events were reported in less than 2% of Zimeta treated horses.2

Dipyrone, the active ingredient in Zimeta, is a member of the non-steroidal anti-inflammatory drug (NSAID) class and has a centrally acting mechanism of action on the hypothalamus where fever originates and is regulated.** This is the first-time dipyrone has been FDA-approved for veterinary use in the United States. Dipyrone, also known as metamizole, is approved and widely used in many other countries.

Directions

Administer Zimeta by intravenous injection, 1 to 2 times daily, at 12 hour intervals, for up to 2 days at a dosage of 20 mg/kg (13.6 mg/lb). The overall number of doses and duration of treatment with Zimeta is dependent on the response observed (fever reduction). Zimeta may be re-administered based on recurrence of fever for up to 3 days. Zimeta is provided in a multi-dose vial and contains a preservative.

Warnings

For use in horses only. Do not use in horses intended for human consumption. Do not use in any food producing animals. Not for use in humans. Keep this and all drugs out of reach of children. In case of accidental exposure, contact a physician immediately.

Contraindications

Horses with hypersensitivity to dipyrone should not receive Zimeta. Due to the prolongation of prothrombin time (PT) and associated clinical signs of coagulopathy, dipyrone should not be given more frequently than every 12 hours.

Human Warnings

Care should be taken to ensure that dipyrone is not accidentally injected into humans as studies have indicated that dipyrone can cause agranulocytosis in humans.

Not for use in humans. Keep this and all drugs out of reach of children. In case of accidental exposure, contact a physician immediately. Direct contact with the skin should be avoided. If contact occurs, the skin should be washed immediately with soap and water. As with all injectable drugs causing profound physiological effects, routine precautions should be employed by practitioners when handling and using loaded syringes to prevent accidental self-injection.

Information for Owners or Person Treating Horse

A Client Information Sheet should be provided to the person treating the horse. Treatment administrators and caretakers should be aware of the potential for adverse reactions and the clinical signs associated with NSAID intolerance. Adverse reactions may include colic, diarrhea, and decreased appetite. Serious adverse reactions can occur without warning and, in some situations, result in death. Clients should be advised to discontinue NSAID therapy and contact their veterinarian immediately if any signs of intolerance are observed.

FAQS

What is Zimeta?

Zimeta is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) of the pyrazolone class used to control fever in horses by veterinary prescription only. Fever is an elevation in body temperature due to a variety of infectious and inflammatory conditions in the horse.

How to Give Zimeta to Your Horse

Zimeta should be given according to your veterinarian’s instructions. Do not change the way you give Zimeta to your horse without first speaking with your veterinarian.

What Kind of Results Can I Expect when my Horse is Being Treated with Zimeta for a Fever?

Zimeta can control fever that is a result of infection or inflammation; however, it is not a cure for the underlying disease. Consult your veterinarian to identify the underlying cause of your horse’s elevated body temperature. Response to Zimeta varies from horse to horse.

Which Horses Should Not Receive Zimeta?

Your horse should not be given Zimeta if he/she:

• Has an allergic reaction to dipyrone, the active ingredient in Zimeta
• Has previously had an allergic reaction to other NSAIDs
• Is presently taking other NSAIDS or corticosteroids including but not limited to aspirin, phenylbutazone, flunixin meglumine, diclofenac, ketoprofen, firocoxib
• The safety of Zimeta has not been determined in horses less than three years of age or in breeding horses, pregnant or lactating mares.

Zimeta Should Be Given Intravenously to Horses Only

Zimeta is not for use in horses intended for human food consumption. Do not use in any food producing animals, including lactating dairy animals. People should not take Zimeta. Keep Zimeta and all medications out of the reach of children. Consult a physician in case of accidental ingestion by humans or accidental injection into humans.

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